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Interestingly, while clinical trials are lacking, there are several disadvantages of these studies in rare diseases that can be easily overcome in the case of SCA3

Yet, these potential benefits of isothiocyanates in cancer therapy have not been explored in clinical trials (72)

However, uptake across the outermost skin layer, the stratum corneum , is considered restricted to nanoparticles smaller than 100 nm [43]

By modulating fatty acid oxidation (FAO) and lipid synthesis, metabolic reprogramming can promote the differentiation of either anti-inflammatory Treg cells or pro-inflammatory Th17 cells: a shift toward FAO enhances Treg cell differentiation, alleviating inflammation

They also showed a decreased incidence of thyroid dysfunction in the postpartum period, better thyroid ultrasound patterns, and decreased permanent hypothyroidism