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The initial model was rigid-body fitted into the consensus EM density map via UCSF Chimera 1.14 32 , followed by manual adjustment using ISOLDE 33 embedded in UCSF ChimeraX 1.6 34

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As a result of this, a multistage carcinogenesis process starts, and cells with diseases may occur by the degradation of the balance between both lipophilic and enzymatic antioxidants that form the antioxidant capacity of skin and ROS