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These efforts involve chemically masking the secondary amine of MK-801 to render it inactive until the linker is cleaved, by the higher concentration of thiol-containing compounds in the intracellular compartment, resulting in liberation of MK-801 18

[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Chaves FM, Wasinski F, Tavares MR, Mansano NS, Frazao R, Gusmao DO, Quaresma PGF, Pedroso JAB, Elias CF, List EO, Kopchick JJ, Szawka RE, and Donato J

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