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SIRT3, which needs NAD+ to work, boosts the cell's antioxidant capacity by increasing NADPH levels and reduced GSH

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In this work, we construct a multiple hydrogen-bond crosslinked hydrogel loaded with tannic acid and Kartogenin by polyaddition reaction as a cell-free scaffold for in vivo cartilage regeneration, which features ultra-durable mechanical properties and stage-dependent drug release behavior