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During injury states, this balance shifts to strongly elevate NOS2 expression specifically in healing contexts

Yishen Tiaojing Formula can effectively inhibit the apoptosis of ovarian granulosa cells and improve ovarian function in rats, which may be related to the down-regulation of pro-apoptotic factors caspase-3 and Bax expression and up-regulation of anti-apoptotic factor Bcl-2 expression [38]

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These findings demonstrate that BPA interferes with estrogen synthesis pathways in both reproductive and neural tissues in a dose-dependent manner

Bertolotto, A., Deisenhammer, F., Gallo, P