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discovered that the proteasome inhibitor MG132 promotes ROS-dependent apoptosis in ELT3 cells by increasing ROS levels in a concentration- and time-dependent manner

It mainly works by inhibiting the parent enzyme named tyrosinase and thus suppresses melanin production

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Perumpail et al

Recent evidence has revealed a new mechanism that IL-23, as a strong inducer of AKT/mTOR signal pathway, can inhibit the autophagy activity ofTFCs, resulting in excessive ROS accumulation [97]