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Improvement of pregnancy rate and live birth rate in poor ovarian responders by intraovarian administration of autologous menstrual blood Derived- mesenchymal stromal cells: phase I/II clinical trial [J]

However, neurotrophins have had little success in clinical trials directed at neurodegenerative diseases due to their poor pharmokinetic profile and large molecular weight that significantly impedes penetration of the BBB [61,62]

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The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation