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If this process is working poorly, then it can lead to conditions like cancer, heart disease, mood disorders, hormonal problems, autoimmunity, dementia and more

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Extraarticular symptoms of severe active RA generally occur in the cardiovascular, respiratory, blood, and urinary system and may cause other comorbidities [2]

In addition, these metabolic effects do not appear to be related to their diuretic action or intended pharmacological targets, raising concerns about the long-term metabolic impact of specific diuretics, particularly in vulnerable populations, including those with metabolic syndrome

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