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REGULATION OF CELLULAR ACTIVITIES THROUGH EPIGENETIC MECHANISMS Alterations in the epigenetic setup are as important as genetic aberrations and may cooperate in cancer genesis

In the tumor microenvironment, oxidative stress promotes the expression of VEGF and tumor angiogenesis, not only providing essential oxygen and nutrients for cancer cells but also involved in removing metabolic wastes [146]

Beyond iron buffering, GSH supports biosynthesis and maintenance of Fe-S clusters, essential cofactors for mitochondrial respiratory enzymes 15

These observations demonstrate that GSH and GSH-rich YE offer a defense against liver damage in ethanol-induced oxidative stress, primarily by enhancing the expression of antioxidant enzymes via the activation of the Nrf2/Keap1 signaling pathway

As to the pi class, GSTP1-1 point mutations in both exon 5 (codon 105) and exon 6 (codon 114) were observed and shown to have an impact on the enzymatic activity 32