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These include illicit drugs, such as marijuana, cocaine, and PCP, as well as prescription medications like opioids, benzodiazepines, and barbiturates

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However, the Academy of Nutrition and Dietetics considers plant and algae sources "unreliable", stating that vegans should turn to fortified foods and supplements instead

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In formal preclinical studies, significant adverse effects are rarely noted, and the compound is generally shown to have a very high safety profile