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Preclinical work has demonstrated the abuse liability of ( R , S )-ketamine is mediated primarily by ( S )-ketamine and involves direct interactions with MORs at doses and concentrations relevant to its reinforcement and antidepressant-like efficacy 18

But, when they leave a fire zone they too become hot or oxidised

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A significant difference was observed at 1, 3, and 10 M doses only

Not for daily use