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It's a hard-and-fast rule that should never be bent if you're serious about your work

Although some of the supplement doses are very high (for instance, 500 or 1,000 micrograms when a healthy adult only needs 2.4 micrograms per day), your body only absorbs what it needs and pees the rest out

This is a significant gap in the literature and represents a genuine safety concern

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So, in summary: FOXO4-DRI appears to represent the next-generation senolytic, offering improved specificity, but it is still earlier stage than many small-molecule senolytics or repurposed drug combinations