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IGFBPs and IGFBP Proteases Like the above attempts to pinpoint the role of important ligands and receptors in the axis, steps to assess the role of IGF binding proteins involved in modulating IGF-I and IGF-II bioactivity were taken (reviewed by Pintar (25))

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Luminal contents can pass across the epithelial barrier via transcellular passive, active or endocytosis mechanisms, or via paracellular pathway