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Collagen production lessens as we age, leading to sagging and wrinkles

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For the preventive experiment, ApoE/ mice were fed with a high-fat diet for 4 weeks, after which they were randomly assigned to five treatment groups and continued on the high-fat diet for an additional month: (I) PBS, (II) Mn/TI@mHSA, (III) P-Mn@mHSA, (IV) P-Mn/TI@mHSA-N, and (V) P-Mn/TI@mHSA ( n = 5 per group

Human clinical evidence There are only two categories of human dataand neither supports its use in arthritis