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To determine the optimal values for the sparsity parameters and the number of components (two) and features (four and five, respectively) 5-fold cross-validation (repeated ten times) was employed

Exosomes could mediate the substance exchange between cells, thereby affecting the biological properties and activities of recipient cells 59

CoQ10 is also a potent anti-inflammatory agent that effectively down-regulates cytokines (i.e., TNF-, IL- 6, CRP) and could optimize viral-disrupted ACE2/RAAS system, by exerting anti-angiotensin II effects and decreasing OxS in COVID-19 patients 537,538