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In contrast, the erastin-induced oxidative stress and cell death could be prevented in HT-1080 and other cancer cell lines by Trolox (a vitamin E analog), the iron chelator deferoxamine (DFO), the MEK inhibitor U0126, and the glutathione peroxidase mimetic ebselen

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It protects the glutathione from being destroyed by stomach acid and allows it to be delivered directly into the bloodstream and eventually to the cells