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This bypass also avoids first-pass metabolism, a process in which nutrients are partially broken down by the liver before they can be used

StatPearls Publishing, Treasure Island Antonelli A, Ferrari SM, Corrado A, Di Domenicantonio A, Fallahi P (2015) Autoimmune thyroid disorders

[1] When both agents place simultaneous load on glutathione-S-transferase pathways, a cautious clinician would want baseline liver function tests (LFTs) and periodic monitoring

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Malignant abnormal cells grow beyond their usual borders, invade adjacent parts surrounding tumor and spread to other organs