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Perlecan, a prominent heparan sulfate proteoglycan in BM, is crucial in BBB maintenance and repair, particularly in pericyte interactions following brain injuries like ischemic strokes [70,71,72]

The insulin secreting -cells, in contrast to the liver, do not express the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) but do express robust levels of the gluconeogenic enzyme pyruvate carboxylase (PC)