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VIP and immune cell modulation VIP interacts with multiple immune cells through specific receptors (VPAC-1, VPAC-2, CRTH2, and PAC1) expressed on eosinophils, mast cells, neutrophils, lymphocytes, dendritic cells, NK cells, and macrophages

Secretogranin-3 (SCG3)-derived peptides also showed enrichment in frail brain, tentatively highlighting aberrant granin function with cognitive frailty

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For multi-level involvement, the systemic effects of TB-500 become even more valuable, as it supports healing throughout the body rather than at a single site