Protein Synthesis Inhibitors-Definition, Examples, Inhibition, Resistance, (2023)
PubMed 22962027 TB-4 Phase 1 human safety first-in-human randomized, double-blind, single- and multiple-dose Phase 1 of recombinant human thymosin 4 in healthy volunteers, no serious adverse events: PubMed 34346165
Even the parent protein (TB4) failed to make it through the approval process
TB-500: 43 amino acids (Thymosin Beta-4 fragment), derived from thymus protein, primary mechanism is actin polymerization and cell migration, most studied for wound healing and cardiac repair
Growth factor receptor interaction studies: Characterizing interactions with GH and IGF-1 receptor pathways in cell-based assays and tissue explant models