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Integrating our data with existing single-nuclear sequencing information, we found subpopulations of cortical SST INs that express signalling genes linked to cognitive resilience, whilst glutamatergic neurons were enriched for cytoskeletal genes associated with frailty 14,20

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+ , K + , and Ca 2+ channels in smooth muscle cells, with the likelihood of altered tubal peristalsis varying in accordance with the drug being administered (Figure 1)