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Research demonstrates that senescent cells upregulate FOXO4 expression as a survival mechanism, using the transcription factor to sequester p53 in the nucleus and prevent its pro-apoptotic signaling cascade

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Michael O'Leary, a urologist at Harvard-affiliated Brigham and Women's Hospital

10.1007/s10278-023-00891-0 113

The other cell types, Huh7.5 and A549, seem to have more active metabolic pathways showing only modest impairment in MTT and CTG in the presence of atpenin A5