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2.5.1 Lipidperoxidation byproducts Quantification of malondialdehyde (MDA) and 4hydroxynonenal (4HNE) in bronchoalveolar lavage fluid (BALF) or exhaled breath condensate provides a direct readout of membrane lipid damage ( 2.5.2 Enzymatic and protein markers GPX4 activity or expression can be measured by ELISA or immunohistochemistry on BALF cells or transbronchial biopsies