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SA-mediated signaling also depends on the intracellular redox status

The highest amount of oxidative stress is in your brain, so the brain requires the highest amount of antioxidants

MN and ES prepared the manuscript

S., Pavlou, M

Although TET members such as TET2 functions as tumor suppressor in certain cancers including AML and glioma 45 , we showed that knockdown of individual TET members consistently abrogates the YBX1AMPK axis in liver and lung cancer cells, suggesting potential functional synergy among TET members in regulating local DNA demethylation, although the underlying mechanisms warrant further investigation