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Downregulation or deficiency of pyruvate kinase leads to ATP depletion which in turn affects cell viability as well as accumulation of the glycolytic intermediates (2,3-diphosphoglycerate (2,3-DPG) that eventually leads to impaired glycolytic flux 46

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Impaired T-lymphocyte proliferation function in biliary atresia patients with chronic cholestatic jaundice after a Kasai operation