However, the longer a therapy continues, the higher and higher the likelihood of improvement regardless of circumstance, especially in an illness with as much natural variability as ME/CFS
4,16,17,18,19,20,21,22 Increased HIF activity in tubular epithelial cells prior to the onset of a toxic or ischemic renal insult appears to diminish the severity of tubular injury, which should be a beneficial effect, but increased expression of HIF in tubular epithelial cells has also been shown to trigger interstitial fibrosis, which is linked to loss of kidney function
A practical compromise involves starting with every-other-day dosing and adjusting based on your response
Holbrook I
The glutaredoxin AtGRXS13 is required to facilitate Botrytis cinerea infection of Arabidopsis thaliana plants