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HK2 expression in tumor cells promotes conversion to aerobic glycolysis, which provides a large amount of energy and leads to excessive glucose uptake, as demonstrated by previous studies

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Gradual weight loss of 710% of body weight, at least 150 minutes of moderate-intensity exercise per week, and dietary improvements (reducing refined carbohydrates and saturated fats whilst increasing vegetables and whole grains) are the most effective interventions for NAFLD