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Long-term safety in humans remains undefined due to absence of extended follow-up studies

HDACi pharmacophore is typically consisting of a metal-binding moiety or functional group, a capping group and a linker

10.1016/j.cgh.2020.02.027 Summary Keywords intestinal permeability, GI diseases, coeliac disease, chronic liver disease, inflammatory bowel disease, bile acid malabsorption, paracellular route, transcellular route Citation Vanuytsel T, Tack J and Farre R (2021) The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation

doi: 10.1089/cbr.2012.1328 [DOI] [PubMed] [Google Scholar] 146.Bepler G, Carney DN, Nau MM, Gazdar AF, Minna JD

GLP-1 analogues may also ameliorate COPD via augmenting normal T-cell functions where T-cell dysregulation is known to contribute to the progression of COPD [99]