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The chronic state of neuroinflammation thus creates an environment that is detrimental to synaptic function and plasticity, contributing to the cognitive and emotional deficits observed in individuals with chronic alcohol use

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doi: 10.3390/nu14061220 94

To assess whether enteric MORs also contribute to morphine-induced constipation in mice, we administered different naloxegol doses (10 mg/kg, 30 mg/kg, and 100 mg/kg, i.p.) at 2 h post morphine treatment (Supplementary Fig