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B12 is safe on its own, but a few conditions call for extra care, which is why a provider reviews your history before treatment: Leber's hereditary optic neuropathy, a rare inherited eye condition, where certain forms of B12 may be a concern for the optic nerve

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Peptide-based weight-loss treatments such as semaglutide (Wegovy) and tirzepatide (Zepbound) are only available by prescription