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Telomere Biology This tetrapeptide has gained significant attention in longevity and anti-aging research based on findings suggesting it can influence telomere length, activate telomerase in somatic cells, normalize circadian rhythms, and potentially extend lifespan in animal models

Similarly, in Alzheimers disease (AD) models, activation of pathways such as the UPS and autophagy pathways is inhibited

Stamataki, N

Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinsons disease, but pathway inhibition results in neuronal necrosis

Saijuntha W, Duenngai K, Tangkawattana S, Petney TN, Andrews RH, Sithithaworn P