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For the CY 2024 reporting period and subsequent years, we estimate a total burden decrease of 160,650 hours (51 hours 3,150 hospitals) at a cost of $7,206,759 (160,650 hours $44.86) related to this proposal

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Cancer has evolved several regulatory mechanisms of ferroptosis, which neutralize ROS and prevent lipid peroxidation, including the xCT-GSH-GPX4 axis [15,42,44] , ferroptosis-suppressor-protein 1 (FSP1)-coenzyme Q10 (CoQ10)-NADPH axis [87] , and Hippo pathway [88]