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Although the decrease in GSH/GSSG was slightly blunted with 4-ClDzp, it was not significantly different from diamide alone, indicating that a decrease in the GSH/GSSG per se is not the only factor required to induce criticality

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Serum thiamine concentration and oxidative stress as predictors of mortality in patients with septic shock. Journal of Critical Care

Mechanisms of arterial stiffening Vascular aging and arterial stiffness are based on multidimensional interactions of intrinsic (e.g., genetics, inflammation) and extrinsic (e.g., environmental) factors over the lifespan