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remota , the acute toxicity tests indicated that the median lethal doses (LD 50 ) of aqueous and 70% ethanol leaf extracts were above 5,000 mg/kg, suggesting that the extracts are not toxic under the tested conditions (166)

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Such imbalances may also contribute to other pathological states, including the early stages of neurodegeneration

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A key event in this activation is the unwinding of the U4/U6 snRNA duplex, followed by the release of the U4 snRNP and B-specific proteins, and the recruitment of various protein complexes such as the NTC (Nineteen), NTR (Nineteen-related), RES (retention and splicing), and IBC (intron-binding) 12,13,14,15,16