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An important tool to assess the pathophysiological relevance of a mode of cell death or a specific mechanism such as LPO is to use a positive control, e.g., APAP + Fe 2+ or APAP in vitamin E-deficient mice

Meanwhile, we measured the levels of lipid peroxidation, a key indicator of ferroptosis, and found that RSL3 treatment completely disrupted the protective effect of uridine (Supplementary Fig

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Very common (more than 1 in 10 people): nausea (18-20%), diarrhea (12-15%), decreased appetite (10-12%)