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And a 2025 systematic review specifically examined BPC-157 from an orthopedic sports medicine perspective, noting the peptide's potential for promoting healing in musculoskeletal injuries including fractures, tendon ruptures, and muscle injuries in preclinical models

Neuron 23 , 583592 (1999)

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Immunohistochemical staining in aged mice showed FOXO4 expression in Leydig cells, often with nuclear localization, whereas it was rarely expressed in young mice