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(2020) 12:e8571-e

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Glycine is synthesized primarily through the enzymatic conversion of serine-by-serine hydroxymethyltransferase (SHMT), which operates in both the cytosol and mitochondria, catalyzing the reversible transfer of a hydroxymethyl group from serine to tetrahydrofolate (THF), producing glycine and 5,10-methylene-THF

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