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However, optimal doses appear tissue- and application-specific, with lower doses often sufficient for gastrointestinal applications while musculoskeletal injuries may benefit from higher dosing

We propose that curcumin exerts its broad therapeutic effects via a unified inflammationoxidative stress axis, primarily by inhibiting NF-B and NLRP3 activation, reducing ROS and pro-inflammatory cytokines (TNF-, IL-1/18), as seen across models of depression, metabolic disorders, and neurodegeneration

Adverse Event Reporting Report adverse reactions to the FDA MedWatch Program at 1-800-FDA-1088 or online at www.fda.gov/medwatch

Here is the practical comparison researchers rely on

W., Arayssi, T., Carandang, K., Deane, K