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Once acetaminophen metabolizes in the liver by conjugation with glucuronic acid (4067%), sulfuric acid (2046%), and p -aminophenol, it easily crosses the blood-brain barrier and is converted to AM404 ( N -hydroxylation in the liver with the involvement of cytochrome P450 enzymes (especially CYP2E1) to form the toxic metabolite, NAPQI (Mitchell et al., 1974

Free Radic Biol Med 2016

Genbank homology search results for cloned sequences in this study

AG is supported by Interdisciplinary Center for Clinical Research (IZKF) at the University of Wrzburg (Z-2/79) and is a Gerok-Position holder funded by the CRC TRR 295 Retune