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Bortezomib, a proteasome inhibitor, showed significant inhibitory and proapoptotic activity in splenocytes and FLSs in a rat model of AIA, altered the inflammatory cytokine pattern by down-regulating the expression of Toll-like receptor 2 (TLR-2), TLR-3, and TLR-4 in FLSs and reduced the invasiveness of FLSs from rats with AIA (Ospelt et al., 2008

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