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Metformin, the first-line oral glucose-lowering agent recommended by NICE for type 2 diabetes (NG28), is well established as a cause of B12 malabsorption

Shortly thereafter, the discovery of the copper-inducible repressor of a copper ATPase (CopY) from Enterococcus hirae , 200 revealed that a metalloregulatory protein could be a member of a protein family better known to elicit a response to small organic molecules, including antibiotics (Section 3.2.5)

Animal studies examining cartilage integrity have noted potential improvements in matrix composition and joint flexibility during recovery periods, making it a research candidate in post-injury musculoskeletal models

458,459 The second domain is comprised of three helices, organized as a pair of three-helix bundles from each protomer and is thus responsible for homodimerization and regulatory metal site binding

Equine candidates for development of therapeutic applications: capabilities and prospects 5.1