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As the amount of the remaining drug in F 6 without any additives was about 40 percent (Table 2), these findings showed that the presence of additives in those has destabilized vitamin B 12 and according to Table 1, PEG and PG 50% v/v as solubilizing and tonicity-adjusting agents, EDTA 0.05% w/v as a chelating agent, S.M.O 0.025%v/v as a surfactant and S.F.S 10% w/v as an antioxidant cannot be considered as stabilizing agents in the case of this study

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