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Multiple studies have reported a higher burden of PCa in men of African ancestry, linked to their West and West-Central African heritage from the transatlantic slave trade, which has been associated with earlier onset and more aggressive tumor behavior compared with men of other ancestries ( Traditionally, the term biomarker is defined as a characteristic that can be measured precisely and reproducibly, and that indicate normal or pathological biological processes, or responses to exposures or interventions ( LAC is characterized by high PCa mortality rates in certain areas and marked ancestral heterogeneity, with populations exhibiting varying proportions of Afro-Caribbean, Native American, and European ancestry shaped by historical processes such as colonization and the transatlantic slave trade

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The NICE recommendations tell GPs to consider testing in anyone with one symptom or one risk factor, and to treat early to prevent neurological damage that can become permanent

Previous drugs have been single- or dual-agonist drugs

For researchers investigating cellular senescence, aging biology, regenerative medicine, and age-related diseases, FOXO4-DRI offers a sophisticated tool that combines mechanistic precision with practical utility, enabling advancement in our understanding of senescence biology and the development of innovative approaches to studying aging and developing research tools for age-related cellular dysfunction