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On the other hand, those with methylation issues (MTHFR gene mutations carriers, for instance) do best on methylated B12, that is, methylcobalamin

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Reduced secretion of gastric acid and pepsin, from the use of H 2 blocker or proton-pump inhibitor (PPI) drugs, can reduce the absorption of protein-bound (dietary) vitamin B 12 , although not of supplemental vitamin B 12