The primary goal of titration is to reduce the severity of gastrointestinal side effects, such as nausea, vomiting, bloating, or diarrhea, which are most common when you start treatment or increase the dosage
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The antinociceptive effect of morphine was shown for a short period, but morphine might have contributed to wound healing
Allergy risk to cobalt or preservatives (rare) Energy improvement: 24-72 hours Reticulocyte response: 3-5 days Neurological improvement: Weeks to months Hematological normalization: 4-8 weeks Maximum nerve repair: Up to 1 year Injection site reactions (15-20%) Mild diarrhea (initial doses) Itching/eczema (cobalt sensitivity) Transient anxiety (overstimulation) Headache (usually resolves quickly) Serious reactions are extremely rare
In an experimental in vitro study, the anti-inflammatory effects of GLP-1RA, exenatide, on human macrophages are predominantly mediated through PKA signaling [71]