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Text Revision American Psychiatric Press: Washington, DC, USA, 2000

First, both MD simulations show that the Cu 3 -TC-Py complex remains bound within the starting groove of the duplex, supporting earlier findings that the complex is a high-affinity DNA binder

Therefore, clinical testing in controlled populations is ultimately required to assess whether this preclinical efficacy is also observed in patients with CRC, both first-line in high-risk patients with high oxidative metabolic signalling (Fig