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Biochim et Biophys Acta (BBA) Mol Cell Res 1868:119001 Han X, Li B, Bao J, Wu Z, Chen C, Ni J, Shen J, Song P, Peng Q, Wan R, Wang X (2022) Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsinB-mediated AP-1 activation

Ingredients with strong evidence and low irritation risk are the best starting point: glutathione, tranexamic acid, azelaic acid, niacinamide, and kojic acid

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Methylene Blue may help with that, too

These supplements typically contain ashwagandha root, leaf, or root/leaf extracts