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B cells are also central to the pathogenesis of RA, contributing to autoantibody production, inflammation, and immune dysregulation, and B cells depletion with anti-CD20 antibody significantly improve RA symptoms (Roll et al., 2006) (Figure 1)

NR contributed to the analysis of data from the Vein-to-Vein database

A recent review summarized that 4-HNE-protein adducts may accelerate inflammation, even acts as autoantigens in the vicious circle of autoimmune diseases [44]