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Additionally, mitochondrial morphological changes were observed in cases when there was no detection of mtDNA mutations and/or changes in oxidative phosphorylation proteins (Liu et al

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Specifically, high intakes of calories, carbohydrates, saturated fats, and sugar coupled with low intake of fiber have been linked to increased risk, while consumption of polyunsaturated fats, fiber, fish, fruits and vegetables, and nuts have been associated with lower risk (Pak 2016)