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If you notice the stopper surface deteriorating or if the vial no longer holds vacuum (you don't hear a slight hiss when first puncturing), replace the vial or transfer contents to a fresh sealed container

And many find it is, but only temporarily

Target-specific surface-anchored proteins function by taking up free haem or extracting it from haemoproteins in the extracellular medium and delivering it to a TonB-dependent outer membrane receptor ( in vivo (Seale et al., 2006)

Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo

Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro